What is the potential side effect of using pyrimidine antagonists for skin cancer treatment?

Pyrimidine antagonists, such as 5-fluorouracil, are used in the treatment of various skin cancers due to their ability to interfere with the synthesis of DNA and RNA, thereby inhibiting the growth of cancer cells. However, one of the notable side effects associated with these drugs is increased sensitivity to sunlight, leading to symptoms such as burning or sunburn-like reactions on the treated skin areas. This is particularly relevant in the context of skin cancer, as patients often receive treatments that are directly applied to the skin.

The photosensitivity can cause discomfort and exacerbate skin damage, making it crucial for patients undergoing this treatment to take precautions, such as avoiding sun exposure and using broad-spectrum sunscreen. By understanding this side effect, healthcare providers can better prepare and counsel patients on managing their treatment and protecting their skin during recovery.